Gonzalez-Sulser Lab

Neuroscience and Epilepsy
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Key roles of C2/GAP domains in SYNGAP1-related pathophysiology.

Katsanevaki D, Till SM, Buller-Peralta I, Nawas MS, Louros SR, Kapgal V, Tiwari S, Walsh D, Anstey NJ, Petrović NG, Cormack A, Salazar-Sanchez V, Harris A, Farnworth-Rowson W, Sutherland S, Watson TC, Dimitrov S,  Jackson AD, Arkell D, Biswal S, Dissanayake KN, NJ, Mizen L, Perentos N, Jones MW, Cousin MA, Booker SA, Chattarji S, Willie DJA, Gonzalez-Sulser A*, Hardt O*, Wood ER*, Kind PC*.

Cell Reports, DOI: 10.1016/j.celrep.2024.114733. 2024.

 

Typical development of synaptic and neuronal propperties can proceed without microglia. O’Keeffe M, Booker SA, Walsh D, Li M, Henley C, de Oliveira LS, Liu M, Wang X, Banqueri-Lopez M, Ridley K, Dissanyake K., Martinez-Gonzales C, Craigie K, Vasoya D, Leah T, He X, Hume DA, Duguid I, Nolan MF, Qiu J, Wyllie DJA, Dando OR, Gonzalez-Sulser A, Gan J, Pridans C, Kind PC, Hardingham GE. BioRxiv Preprint.

DOI: https://doi.org/10.1101/2024.09.06.611614.

 

Preictal Period Optimization for Deep Learning-Based Epileptic Seizure Prediction.

Koutsouvelis P, Chybowski B, Gonzalez-Sulser A, Abdullateef S, Escudero J.

arXiv Preprint.

DOI: https://doi.org/10.48550/arXiv.2407.14876. 2024.

 

 

Absence seizures and sleep abnormalities in a rat model of GRIN2B related disorder.

Hristova K*, Fasol CM, McLaughlin N, Nawaz S, Taskiran M, Buller-Peralta I, Bassi A,Ocampo-Garces A, Kind PC, Gonzalez-Sulser A.

BioRxiv Preprint. DOI: https://www.biorxiv.org/content/10.1101/2024.02.27.582289v1. 2024.

 

Face-valid phenotypes in a mouse model of the most common mutation in EEF1A2-related neurodevelopmental disorder.

Marshall GF, Fasol M, Davies FCJ, Le Seelleur M, Alvarez AF, Bennett-Ness C, Gonzalez-Sulser A, Abbott CM.

Disease Models & Mechanisms. DOI: https://doi.org/10.1242/dmm.050501. 2024.

 

Single-Channel EEG Artifact Identification with the Spectral Slope.

Fasol M, Escudero J*, Gonzalez-Sulser A*. IEEE International Conference on Bioinformatics and Biomedicine (BIBM). DOI: 10.1109/BIBM58861.2023.10385840. 2023.

 

Reversal of cell , circuit and seizure phenotypes in a mouse model of DNM1 epileptic encephalopathy.

Bonnycastle K, Dobson, K L, Blurich E-M, Gajbhiye A, Davenport EC, Pronot M, M Steinruecke, M Trust, Gonzalez-Sulser A, Cousin MA.

Nature Communications. 14, article 5285. DOI: https://doi.org/10.1038.s41467-0223-41036-w. 2023.

 

Abnormal brain state distribution and network connectivity in a SYNGAP1 rat model.

Buller-Peralta I*, Maicas-Royo J*, Lu Z*, Till SM, Wood ER, Kind PC, Escudero J, Gonzalez-Sulser A.

Brain Communications. 4, 6. DOI: fcac263. 2022.

 

New inroads into the brain circuits and network dynamics behind sudden unexpected death in epilepsy. Gonzalez-Sulser A.

Brain Communications. 4, 2. DOI: fcac097, 2022.

 

Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation.

Hristova K*, Martinez-Gonzalez C*, Watson TC*, Codadu NK, Hashemi K, Kind PC, Nolan MF, Gonzalez-Sulser A.

Brain. 144, 5: 1576–1589. DOI: /brain/awaa045, 2021.

 

Modelling epilepsy in the mouse: challenges and solutions.

Marshall GF, Gonzalez-Sulser A, Abbott CM.

Disease Models & Mechanisms. dmm047449 doi: 10.1242/dmm.047449, 2021.

 

Rodent genetic models of neurodevelopmental disorders and epilepsy.

Gonzalez-Sulser, A.

European Journal of Paediatric Neurology. 24:66-69, 2020.

 

Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease.

Brown, R*, Lam*, A, Gonzalez-Sulser, A*,  Ying A, Jones M, Chou R, Tzioras M, Jordan C, Jedrasiak-Cape I, Hemonnot A, Jaoude MA, Cole A, Cash S, Saito T, Saido T, Ribchester R, Hashemi K, Oren I.

eNeuro. 17;5(2), 2018.

 

Grid cells’ need for speed.

Gonzalez-Sulser A, Nolan MF.

Nature Neuroscience. 20, 1-2, 2017.


GABAergic projections from the medial septum selectively inhibit interneurons in the medial entorhinal cortex.

Gonzalez-Sulser A, Parthier D, Candela A, McClure C, Pastoll H, Garden D, Sürmeli G, Nolan MF.

Journal of Neuroscience. 34(50):16739-43, 2014.


Hippocampal neuron firing and local field potentials in the in vitro 4-aminopyridine epilepsy model.

Gonzalez-Sulser A, Wang J, Queenan BQ, Avoli M, Vicini S, Dzakpasu R.

Journal of Neurophysiology (9): 2568-580, 2012.

 

Cellular mechanisms of desynchronizing effects of hypothermia in an in vitro epilepsy model. Motamedi GK, Gonzalez-Sulser A, Dzakpasu R, Vicini S.

Neurotherapeutics(1): 199-209, 2012.

 

The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. Gonzalez-Sulser A*, Wang J*, Motamedi GK, Avoli M, Vicini S, Dzakpasu R,

Neuropharmacology. (60): 1142-1153, 2011.

 

Analgesic effects of sazetidine-A, a new nicotinic cholinergic drug.

Cucchiaro G, Xiao Y, Gonzalez-Sulser A, Kellar KJ.

Anesthesiology. 109 (3):512-9. 2008.

 

Electrophysiologic effects of systemic and locally infused epibatidine on locus coeruleus neurons. Ganesh A, Gonzalez-Sulser A, Chaijale N, Cucchiaro G.

European Journal of Pharmacology. 14; 584 (1) :93-9, 2008.

 

Nuclear processing and export of microRNAs in Arabidopsis.

Park MY, Wu G, Gonzalez-Sulser A, Vaucheret H, Poethig RS.

Proceedings of the National Academy of Sciences. 8; 102(10):3691-6, 2005.

 

*=Co-authorship.